Gluco 1 за кръвна захар и контрол на глада от д-р Неделя Щонова
Gluco1 - blood sugar control
Gluco1 - blood sugar control
Gluco1 - blood sugar control
Gluco1 - blood sugar control
Metabolic formula for blood sugar and appetite

Gluco 1

Blood sugar and appetite control the natural way. A formula by Dr. Nedelya Shtonova with four ingredients that maintain steady glucose levels throughout the day and reduce post-meal spikes.

400 mg berberine 4 ingredients Developed by a doctor 🇪🇺 Made in EU GMO-Free
Purchase options
Delivery to an address or courier office
Your order will arrive within 1–2 business days · Get free delivery on orders over €60
Question before ordering?
Call 02 408 5577 · We are open Mon–Fri 9:00–17:00
Registered in the BFSA register under No. Т162502003/25.03.2025
Manufactured in the EU under GMP standards
How to take

2 capsules daily with your two largest meals. It does not matter what time of day you consume more food, just take one capsule before each such meal. One pack of 60 capsules is enough for exactly 30 days.

What does it contain

60 capsules containing some of the most studied ingredients for natural blood sugar control. Berberine (Berberis aristata), R-alpha lipoic acid, Milk thistle (Silybum marianum), Chromium picolinate.

Delivery and Payment

We ship within one business day; delivery takes 1–2 business days to an address or courier office. Shipping is free for orders over €60. You can pay by card online or in cash upon delivery.

Who is it suitable for

For adults and children over 12 years of age who want balanced blood sugar and stable energy, especially with frequent carbohydrate intake, cravings for sweets, or a predisposition to insulin resistance. Not recommended during pregnancy and breastfeeding. If taking medication, see the "I take medication. Can I?" section below.

Four investigated ingredients Each with proven benefits
Developed by a doctor Dr. Nedelya Shtonova's formula
Authorized claim in the EU For normal blood sugar
Compatibility verified The ingredients are safe even during therapy
calm range breakfast lunch 16:00 dinner
A more equal day Ups and downs quiet range
How it works

This is your blood sugar curve for the day.

At 4:00 PM, you don't lack energy; you lack a stable curve. After a heavy meal, your blood sugar spikes, your body responds with a large dose of insulin, and an hour later comes the crash, which your brain translates as "I want something sweet, and I want it now." Gluco 1 works precisely on this curve with four ingredients that intercept the process at four different points.

The post-meal peak

The steeper the blood sugar spike, the steeper the subsequent crash. Berberine is the most researched plant-based ingredient specifically for this aspect. It activates AMPK, the "low-fuel switch" in the cell, which opens the doors for glucose to enter the muscle.

AMPK is the sensor the cell uses to decide whether to store or burn energy. When activated, muscle cells move more GLUT4 transporters to their surface and take up more glucose from the blood, while the liver produces less new sugar. Berberine is poorly absorbed, which is why it also works in a second location – the intestines themselves – where it has a beneficial effect on the microbiome.

The 4:00 PM slump and the craving for sweets

Chromium does not add insulin; it helps your own insulin work more effectively. It is an ingredient with an EU-approved health claim for blood sugar control.

The mechanism has a name: chromodulin. When insulin attaches to its receptor, the body mobilizes this small peptide, which carries four chromium ions and keeps the receptor switched on for longer. The signal becomes stronger and clearer, and the result is more glucose entering the cell instead of circulating in the blood. This is the origin of the authorized wording: "Chromium contributes to the maintenance of normal blood glucose levels."

The liver - the silent regulator

Most people think of the pancreas. But the organ that stores sugar and releases it back is the liver. When it is overloaded, the curve fluctuates regardless of what is on your plate.

Milk thistle (silymarin) is one of the most researched plant ingredients for liver cells: it acts as an antioxidant, stabilizes the cell membrane, and helps the hepatocyte maintain its own protection. R-alpha lipoic acid completes the picture from another angle. It is one of the few antioxidants that dissolve in both water and fat, works as a cofactor in the mitochondria, and restores depleted vitamin C, vitamin E, and glutathione.

Three things that are changing

Less need for sweets

When the curve is flatter, the craving for quick sugar stops coming in waves. The most common thing people write to us after the first month is exactly this: "I don't feel the need to eat sweets."

Craving sweets at a certain time is a matter of physiology. The brain wants quick glucose because it has just sensed a drop. That is why the solution is rarely more discipline. It is more about having more protein and fiber on your plate, movement after eating, and support for normal metabolism. Gluco 1 is the support for when you don't have the opportunity to be perfect in your daily routine.

No afternoon drowsiness

It’s 4:10 PM, you’re staring at the screen and not reading, because your eyes are glazing over. It’s not age and it’s not laziness; it’s the crash following the sugar spike from lunch. A smoother curve is the difference between "getting through the day" and "getting work done."

The brain weighs about 2% of your body, yet it consumes about 20% of your glucose. It has no storage facility to keep it in. It operates entirely on real-time delivery, which is why it feels every peak and every dip more acutely than any other organ. That is why stable blood sugar is felt first as a clear mind.

Antioxidant support for the liver

The formula does not only look at blood sugar. Milk thistle and alpha-lipoic acid take care of the organ that regulates glucose and the cells that suffer first from oxidative stress.

Alpha-lipoic acid is called the "universal antioxidant" because it works in both the aqueous and fatty parts of the cell, and because it regenerates other antioxidants instead of simply being used up. Milk thistle is the traditional European ingredient for supporting liver function and is recognized by a European Medicines Agency monograph.

See table with composition per daily dose · 2 capsules

Four ingredients for a real result.

An ingredient listed on the label without a weight is a name, not a dose. That is why Gluco 1 fits into four lines and does not include a vague "proprietary blend" to hide quantities behind. You can compare them one by one, as well as read about their effects.

See table with composition per daily dose · 2 capsules
Ingredient In 2 capsules
Berberine (Berberis aristata) 400 mg
R-alpha lipoic acid 200 mg
Milk thistle (Silybum marianum) 200 mg
Chromium picolinate 200 µg · 500% RDA*

*RI — reference intake (for chromium it is 40 µg).

EU authorizes health claim regarding blood sugar.

There is no need for advertising when the action is proven.

"Chromium contributes to the maintenance of normal blood glucose levels" and "Chromium contributes to normal macronutrient metabolism".

This is not a marketing catchphrase, but an officially authorized health claim under Regulation (EU) No 432/2012 - the list of claims permitted for use on foods in the European Union. Most blood sugar supplements do not have a single such statement. Gluco 1 contains the amount that triggers it.

200 µg
chromium picolinate in the daily dose — in the form permitted for foods and food supplements
500%
of the reference daily intake (40 µg) — over 30 times more than necessary to ensure the effect
below 250 µg
the ceiling up to which EFSA deems chromium picolinate intake to be safe. We remain below it for your safety.
Food supplement. Not a medicine and does not replace a varied diet and a healthy lifestyle.
Your 60-day plan

We don't offer overnight miracles. We offer a routine that works.

Metabolism doesn't reset in a week. That is why we think months ahead, not in days.

Day 1–7 · The body gets used to it.

Start with one capsule with your two largest meals. The four ingredients become part of your daily routine, and the only thing you need to do is take them with/before a meal.

Tip: place the box next to the plate, not in the cupboard. Taking it with food becomes a habit from day one.

The most frequent question we receive

"I am taking medication. Can I have some too?"

We have reviewed the ingredients line by line against the dozens of therapies you are asking us about. The good news is that for most of them, there is absolutely no issue with taking Gluco 1. For a few, there are minor considerations. And there is a short, honest list for which our answer is "no". Read it so you can be reassured, not surprised.

✓ Insulin resistance without medicationAbsolutely fine — Gluco 1 was created for exactly this profile.
✓ Prediabetes without therapyAbsolutely fine. There is no data on any problem when you are not taking blood sugar medication.
✓ Hashimoto’s without medicationAbsolutely fine — the ingredients have no established interaction with Hashimoto’s when you are not on therapy.
✓ Antidepressants (SSRIs)Based on available data, there is no established interaction. You can take it.
✓ Gastritis and refluxYes — with one note: always with food, never on an empty stomach.
✓ High blood pressure (without losartan)Yes. Monitor your readings for the first few weeks and tell your cardiologist at your next check-up.
✓ Euthyrox / levothyroxineYes — just separate the intake: the hormone in the morning on an empty stomach, Gluco 1 at least 4 hours later, with food.
✓ Other Sapphire productsCombines with the whole range — the formulas are made to complement each other.
✓ ContraceptivesNo established interaction with the ingredients.
! Diabetes medication (metformin, Siofor, Glucophage, insulin)We recommend agreeing it with your doctor: both act on blood sugar, so doses and monitoring are their decision.
! Statins, sildenafil, sedativesBerberine may affect how they are broken down. For your own peace of mind, tell your doctor you are taking the supplement.
! Losartan (Lorista)Here it is the opposite of what you might expect: berberine may weaken its effect. Ask your doctor before combining them.
✕ Pregnancy and breastfeedingWe do not recommend taking it during this period. Our answer here is always the same.
✕ Children under 12The formula is for adults and children over 12.
✕ Ciclosporin, tacrolimus (after a transplant)Do not take it — this is a documented interaction, not over-caution.
✕ G6PD deficiency (favism)Not suitable with this deficiency.

The review is at an ingredient level and is intended to provide you with an accurate starting point, but it does not replace the opinion of your attending physician.

How is it taken?

One capsule with each main meal.

Rule #1: always with/before food

One capsule with each of the two largest meals of the day. This ensures the ingredients are there where there is something to balance, and the stomach tolerates them much better.

If you feel a slight heaviness in the first few days, do not stop taking it, but move the capsule to the middle of the meal, instead of before it.

What do the studies show about tolerability?

The broad summaries are reassuring: in an analysis of 12 placebo-controlled studies, adverse reactions to berberine did not differ from those of the placebo, and in an analysis of 37 studies, they were even lower than in the control group.

The situation with alpha-lipoic acid is the same: a review of 71 randomized studies with 4,749 participants found no increased risk of adverse reactions compared to placebo, including in people with diabetes, cardiovascular, and kidney conditions.

morninglunchdinner 2 capsules a day 1 with each of the two largest meals with food · not on an empty stomach · at the same time every day
capsule the moment of intake

The most researched ingredients in the world

Here is what research shows about berberine, alpha-lipoic acid, milk thistle, and chromium. Swipe with your finger or mouse and tap the card for details and the source.

What those who tried it have to say:

Reviews are personal impressions of customers and do not describe the effect of the product. Results are individual.

Why we created Gluco 1
"Between 'healthy' and 'diagnosis' lies a wide gray area where many people live. There, no treatment is provided; instead, the focus is on maintenance."
Dr. Nedelya Shtonova
Dr. Nedelya Shtonova
creator of the Sapphire formulas

Your test results are normal. Your blood sugar is normal. And yet, something is not right: you feel sleepy after meals, you're exhausted in the afternoon, and the weight is piling up around your midsection. That is exactly why I created Gluco 1—to help maintain normal levels while you take care of your diet, exercise, and sleep. When I put my name on a product, it is not marketing. It is a personal responsibility.

Frequently Asked Questions

How does Gluco 1 work?

It regulates blood sugar, helping to avoid sharp fluctuations and excessive insulin secretion. It supports metabolism, reduces intense hunger, and maintains stable energy throughout the day. The four ingredients work at four different sites: berberine works in the cell and in the gut; chromium on insulin signaling; milk thistle on the liver; and alpha-lipoic acid as an antioxidant.

How many capsules are in the package and how long do they last?

The packaging contains 60 capsules. With the recommended intake of 2 capsules daily, it lasts exactly 30 days - one full month. The 2-pack covers 60 days, and the 3-pack covers 90 days.

When and how much should I take?

Up to 2 capsules daily, with food. One with each of the two largest meals. Taking it with food is important: this way, the ingredients are where there is something to balance, and the stomach tolerates them more easily.

Is it suitable for me?

An excellent choice if you frequently consume carbohydrates, if your energy is unstable throughout the day, if sugar cravings come in waves, or if you have a tendency toward insulin resistance. You don't need a formal diagnosis to think about your balance.

What age is it suitable for?

For adults and children over 12 years of age. For a child with a diagnosed condition or undergoing therapy, intake should be evaluated by the attending physician, regardless of age.

When will I feel a difference?

Most people notice the difference in their afternoons between the second and third week. More freshness in the afternoon and a less frequent craving for sweets. However, metabolism changes slowly: think in terms of 60 days, not just days.

How long can I take it?

It is suitable for prolonged, daily use. For more significantly disturbed balance, the usual course is at least 1–2 months; for maintenance — 3-6 month courses. There is no requirement for a break.

Will it help me lose weight?

Gluco 1 is not a weight loss product and will not promise you weight loss. But when the sugar curve is more stable, the increased waves of hunger decrease, and for many people, this has been the obstacle. It is a support to your diet, exercise, and sleep, but not a substitute.

I am taking medication for type 2 diabetes. Can I?

Only after consulting with your attending physician. Both the therapy and the ingredients affect blood sugar, so dosages and monitoring are their decision — this is not a refusal, but the correct procedure. Message us privately and we will send you the full composition with the amounts, so you can take it to your appointment.

I am taking Euthyrox / levothyroxine. Is it okay for me to?

You can — just split the doses. The hormone should be taken in the morning on an empty stomach, and Gluco 1 at least 4 hours later, with food. This way, the two do not interfere with each other. For your peace of mind, mention the supplement to your endocrinologist at your next check-up.

I have insulin resistance, but I am not taking medication. Can I?

Yes, absolutely fine — Gluco 1 is designed precisely to provide support for such a profile, and there is no evidence of any issues when you are not taking sugar-regulating medication.

Are there any side effects?

The ingredients have a very good safety profile. In summaries of dozens of studies, adverse reactions to berberine and alpha-lipoic acid do not differ from placebo.

Can I combine it with other supplements?

Yes, provided the daily doses of the ingredients are not exceeded. It can be combined with all Sapphire products, as the formulas are designed to complement one another.

Is it safe during pregnancy and breastfeeding?

We do not recommend use during pregnancy and breastfeeding. Our answer here is always the same, without exception.

Is there scientific evidence behind the formula?

Yes. The four ingredients are among the most researched in the field of metabolism with dozens of randomized studies and meta-analyses, and chromium also has an officially authorized health claim in the EU. In the "Most researched ingredients in the world" section above, we have listed the specific sources, including author, publication, and issue number.

Where can I buy it in person?

In addition to online, Gluco 1 is also available at the DM drugstore chain, Subra Pharmacies, 36.6 Pharmacies, and Nove Pharmacies.

Are you ready to start?

60 days is the period during which glucose levels stabilize.

The 2-pack bundle covers 60 days and will cost you €0.92 per day, with free shipping.

Select a package

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